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SELECTED
BIOMEDICAL GROUP REFERENCES |
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SRBF Groups
Cytokines and Inflammation Group
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Cytokines
& Inflammation Group Emsley HCA, Hopkins SJ.
(2008) Acute ischaemic stroke and infection: recent and emerging concepts.
The Lancet Neurology 7:341-53. Emsley HCA, Smith CJ,
Tyrrell PJ, Clark
SR, McMahon CJ, Gueorguieva I, Rowland M, Scarth S, Georgiou R, Tyrrell PJ,
Hopkins SJ, Rothwell NJ. (2007) Interleukin-1 receptor antagonist penetrates
human brain at experimentally therapeutic concentrations. J Cereb Blood Flow
Metab. (2008) 28: 387–394 Emsley
H, Smith C, Gavin C, Georgiou R, Vail A, Barberan E, Illingworth K,
Scarth S, Wickramasinghe V, Hoadley M,
Rothwell N, Tyrrell P, Hopkins S (2007) Clinical outcome following acute
ischaemic stroke relates to both activation and autoregulatory inhibition of
cytokine production. BMC Neurology 7:5 doi:10.1186/1471-2377-7-5 Smith
CJ, Emsley HCA, Vail A, Georgiou RF, Rothwell NJ, Tyrrell PJ, Hopkins SJ.
(2006) Variability of the systemic acute phase response after ischemic
stroke. Journal of Neurological Sciences 251:77-81. Hoadley
ME, Hopkins SJ. Comparison of ‘Real-Time’ and Immunometric RT-PCR: RNA
Interference of Reverse
Transcriptase-PCR. J Immunol Methods. 2006; 312, 40-44. Emsley, C.A., Smith, C.J., Georgiou, R.F., Vail, A.,
Hopkins, S.J., Rothwell, N.J., Tyrrell, P.J. (2005) A randomised phase II
study of interleukin-1 receptor antagonist in acute stroke patients. J.
Neurol. Neurosurg. Psychiatry. 76, 1366-1372. Smith,CJ;
Emsley,CA; Gavin,CM; Georgiou,RF; Vail,A; Barberan,EM; del Zoppo,GJ; HallenbeckJM; Rothwell,NJ;
Hopkins,SJ; Tyrrell,PJ (2004): Peak
plasma interleukin-6 and other peripheral markers of inflammation in
the first week of ischaemic stroke
correlate with brain infarct volume,
stroke severity and long-term outcome. BMC Neurol. 4:2, http://
www.biomedcentral.com/1471-2377/4/2. Emsley,
H.C.A., Smith, C.J., Gavin, C.M., Georgiou, R.F., Vail, A., Barberan, E.M.,
Hallenbeck, J.M., del Zoppo, G.J., Rothwell, N.J., Tyrrell, P.J., Hopkins,
.S.J. (2003): An early and sustained peripheral inflammatory response in
acute ischaemic stroke: relationships with infection and atherosclerosis. J.
Neuroimmunol. 139, 93-101. Hopkins, S.J. (2003) The
pathophysiological role of cytokines. Legal Med 5, S45-57 Turnbull,
A.V., Prehar, S., Kennedy A.R., Little R.A., Hopkins S.J. (2003)
Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis
during local inflammation in mice. Endocrinology 144, 1894-1906. Zampronio,
A.R., Melo, M.C.C., Hope,
J.C., Warhurst,
A.C, Miller, A. J., Miller,A. J., Luheshi, G., Rothwell, N. J.
& Hopkins, S. J. (1997) Local
cytokine induction by lipopolysaccharide in the rat air pouch and its
relationship to the febrile response. Am. J. Physiol. (Endocrinol. Metab.) 41,
R857-R861. Luheshi, G., Miller,A. J., Brouwer, S., Dascombe, M.
J., Rothwell, N. J. & Hopkins, S.
J.,(1996) Interleukin-1 receptor antagonist inhibits endotoxin fever and
systemic interleukin-6 induction in the rat. Am. J. Physiol. 270,
(Endocrinol. Metab. 33): E91‑E95. Hopkins, S. J. & Rothwell, N.J. (1995) Cytokines
and the nervous system: I Expression and recognition. Trends in Neuroscience 18,
83- 88. Davidson
Y, Amin H, Kelley T, Shi J, Tian J, Lashley T, Bandopadhyay R, DuPlessis D,
Neary D, Snowden JS, Sikkink S, Pickering-Brown SM, David M.A. Mann (2009) TDP-43 in ubiquitinated inclusions in the inferior olives in
frontotemporal lobar degeneration and in other neurodegenerative diseases; a
degenerative process distinct from normal ageing. Acta Neuropathol (in press). Foulds PG, Davidson Y, Mishra M, Johnson N, Weintraub S,
Akiyama H, Arai T, Hasegawa M, Bigio EH, Allsop D, Mann DMA (2009) Plasma
TDP-43 protein levels correlate with brain pathology in frontotemporal lobar
degeneration. Acta Neuropathol (in press). Rollinson S, Rohrer JD, van der Zee J, Sleegers
K, Mead S, Engelborgs S, Collinge J, Rossor M, De Deyn PP, Mann DMA,
Van Broeckhoven C, Pickering-Brown SM (2009) No association of PGRN 3’UTR rs5848 in frontotemporal
lobar degeneration. Neurobiol Aging (in press). Pickering-Brown S,
Rollinson S, Du Plessis D, Morrison KE, Varma A, Richardson AMT, Neary D,
Snowden JS, Mann DMA (2008) Frequency and clinical characteristics of
progranulin (PGRN) mutation
carriers in the Manchester frontotemporal lobar degeneration cohort: comparison to patients with tau (MAPT)
and no known mutation. Brain 131; 721-731. Foulds P, McAuley E, Gibbons L, Davidson Y, Pickering-Brown SM,
Neary D, Snowden JS, Allsop D, Mann DMA (2008) TDP-43 protein in plasma may index TDP-43 brain pathology in
Alzheimer’s disease and frontotemporal lobar degeneration. Acta Neuropathol 116;
141-146. Davidson
Y, Kelley T, Mackenzie IR, Pickering-Brown SM, Du Plessis D, Neary D, Snowden
JS, Mann DMA (2007) Ubiquitinated pathological lesions in frontotemporal
lobar degeneration contain the TAR DNA-binding protein, TDP-43. Acta
Neuropathologica 113: 521-533. Davidson
Y, Gibbons L, Pritchard A, Hardicre J, Wren J, Stopford C, Julien C, Thompson
J, Payton A, Pickering-Brown SM, Pendleton N, Horan MA, Burns A, Purandare N,
Lendon CL, Neary D, Snowden JS, Mann DMA (2007) Apolipoprotein E ε4 allele frequency and age at onset of
Alzheimer’s disease. Dementia
Geriatr Cogn Disord 23; 60-66. Snowden
JS, Pickering-Brown SM, Du Plessis D, Mackenzie IR, Varma A, Mann
DMA, Neary D (2007) Progressive Anomia revisited: focal
degeneration associated with progranulin gene mutation. Neurocase 13;
366-377. Rollinson S, Snowden JS, Neary
D, Morrison KE, Mann DMA, Pickering-Brown SM (2007) TDP-43 gene analysis in
frontotemporal lobar degeneration. Neurosci Lett 419; 1-4. Snowden JS, Stopford C, Julien C, Thompson JC, Davidson Y, Gibbons L, Pritchard A, Lendon CL, Richardson A, Varma A, Neary D, Mann DMA (2007) Cognitive phenotypes in Alzheimer’s disease and genetic risk. Cortex 43; 835-845. Davidson
Y, Gibbons L, Pritchard AH, Hardicre J, Wren J, Tian J, Shi J, Stopford C,
Julien C, Thompson J, Payton A, Thaker U, Hayes AJ, Iwatsubo T, Lendon CL,
Pendleton N, Horan MA, Burns A, Neary D, Snowden JS, Mann DMA (2006) Genetic association between cathepsin D
exon 2 C>T polymorphism and Alzheimer’s disease, with pathological
correlations with genotype. J Neurol Neurosurg Psychiatry 77;
515-517. Shiarli AM,
Jennings R, Shi J, Bailey K, Davidson Y, Tian J, Bigio E, Ghetti B, Arima K,
Iseki E, Murayama S, Kretzchmar H, Lippa C, Halliday G, MacKenzie J, Khan N,
Ravid R, Dickson D, Wszolek Z,
Iwatsubo T, Pickering-Brown SM, Mann DMA (2006) Comparative tau pathology in
Frontotemporal Lobar Degeneration and Alzheimer’s disease. Neuropathol Appl Neurobiol
32; 374-387.
Shi J, Tian J, Pritchard A, Lendon C, Lambert JC,
Iwatsubo T, Mann DMA (2006) A 3’-UTR polymorphism
in the oxidized LDL receptor 1 gene increases Aβ40
load as cerebral amyloid angiopathy in Alzheimer’s disease. Acta Neuropathol 111;
15-20. Tian J, Shi J, Smallman R, Iwatsubo T,
Mann DMA (2006) Relationships in Alzheimer’s disease between the extent of Aβ deposition in cerebral blood vessel walls, as
cerebral amyloid angiopathy, and the amount of cerebrovascular smooth muscle
cells and collagen. Neuropathol Appl Neurol 32; 332-340. de Silva R, Lashley T, Strand K, Shiarli A-M, Shi J, Bailey KL, Bigio
EH, Arima K, Iseki E, Murayama S, Kretzschmar H, Neumann M, Lippa C, Halliday
G, MacKenzie J, Ravid R, Dickson D, Wszolek Z, Iwatsubo T, Pickering-Brown SM,
Holton J, Lees A, Davies P, Revesz T, Mann DMA (2006) An immunohistochemical
study of cases of sporadic and inherited Frontotemporal lobar degeneration
using 3R- and 4R-specific tau monoclonal antibodies. Acta Neuropathol 111;
329-340. Mackenzie IRA, Shi J, Shaw CL, Du Plessis D, Neary
D, Snowden D, Mann DMA (2006) dementia lacking distinctive histology (DLDH)
revisited. Acta Neuropathol 112; 551-559. Mackenzie IRA, Baborie
A, Pickering-Brown SM, Du Plessis D, Jaros E, Perry RH, Neary D, Snowden JS,
Mann DMA (2006) Heterogeneity of ubiquitin pathology in frontotemporal lobar
degeneration: classification and relation to clinical phenotype. Acta
Neuropathol 112; 539-549. Snowden JS,
Pickering-Brown SM, Mackenzie IR, Richardson AMT, Varma A, Neary D, Mann DMA
(2006) Progranulin gene mutations associated with frontotemporal dementia and
progressive aphasia. Brain 129; 3091-3102. Davidson
Y, Gibbons L, Purandare N, Byrne J, Hardicre J, Wren J, Payton A, Pendleton
N, Horan A, Burns A, Mann DMA (2006) Genetic risk factors and vascular
dementia. Dementia Geriatr Cogn Disord 22; 15-19. Pickering-Brown
SM, Baker M, Gass J, Boeve BF, Loy CT, Brooks WS, Mackenzie IR, Martins RN,
Kwok JB, Halliday GM, Kril JJ, Schofield PR, Mann DM, Hutton M (2006)
Mutations in progranulin explain atypical phenotypes with variants in MAPT.
Brain 129; 3124-3126. Dark P., Dean P., Warhurst
G. (2009) From bench-to-bedside: the promise of rapid infection diagnosis
using PCR-based pathogen detection Critical Care, (In press) Hafez M, Hayes K, Goldrick
M, Warhurst G, Grencis RK, Roberts IS (2009). The K5 capsule of Escherichia
coli strain Nissle 1917 is important in mediating interactions with
intestinal epithelial cells. Infection and Immunity 77: 2995-3003 Collett A, Stephens RH,
Harwood M, Humphrey M, Dallman L, Bennett J, Carlson GL, Warhurst G. (2008)
Investigation of regional mechanisms responsible for poor oral absorption in
man of a controlled release preparation of the -adrenoreceptor
antagonist, UK-338,003: the rational use of ex vivo intestine to predict in
vivo absorption. Drug Metabolism and Disposition 36: 87-94 Collett, A., Higgs, N.B. Zeef,
L.A. Hayes, A. Salmo, E, Haboubi, N, Carlson, G.L., Warhurst G. (2008)
Changes in mucosal expression of bacterial response and epithelial
repair genes precede altered gut
permeability during colitis development in mdr1a (-/-) mice. Inflammatory
Bowel Diseases 14: 620-31 Macutkiewicz, C, Carlson
GL, Clark EC, Dobrindt U, Roberts IS,
Warhurst G. (2008) Characterisation of commensal E. coli strains involved in
transcytosis across gut epithelial cells exposed to metabolic and inflammatory
stress. Microbes and Infection 10: 424-31. Edwards-Ingram LC, Gitsham
P, Warhurst G, Clarke I, Terentjev Y, Hoyle D, Oliver SG, Stateva LI. (2007)
Genotypic and physiological characterization of Saccharomyces boulardii, the
probiotic strain of S. cerevisiae. Applied
and Environmental Microbiology, 73:2458-67 Gunji, H., Collett, A. J.
Tanianis-Hughes, GL Carlson, M. Harwood, G. Warhurst Comparison of P-glycoprotein-mediated drug
interactions in Caco-2 with human and rodent intestine: relevance to in vivo
prediction. European J. Pharmaceutical Sciences 26: 386-393 (2005) Watson C.J., Hoare C.,
Garrod D.R. Carlson G.L., G Warhurst (2005) Interferon-gamma selectively
increases epithelial permeability to large molecules by activating different
populations of paracellular pores. Journal of Cell Science 118: 5221-5230 Collett A, J. Tanianis-Hughes,
G. Warhurst (2004) Rapid induction of P-glycoprotein expression by high
permeability compounds in colonic cells in vitro: a possible source of
transporter mediated drug interactions? Biochemical Pharmacology 68: 783-790. Clark, EC, S. Patel,
Currie, A., G. Warhurst, G.L. Carlson (2003) Acute deprivation of glutamine
as a metabolic fuel facilitates TNF- induced bacterial translocation. Gut 52: 226-232. Watson C.J., M. Rowland,
Warhurst G (2001) Functional modelling
of tight junctions in colonic epithelial monolayers using PEG oligomers. Am.
J. Physiol 281: C388-C397 Mahmood B., Warhurst, G.,
Higgs, N.B., Turnberg L.A. (2000) Carbachol potentiates cholera toxin-induced
secretion in a colonic epithelial cell line (HT29-19A) and rat ileal mucosa
in vitro J. Health Popul. Nutr. 18: 49-53 (2000) Stephens, R.H., O’Neill, Warhurst, A.C., Hopkins,
S.H., Warhurst, G., (1998)
Interferon-γ induces a differential up-regulation of α- and
β- chemokine secretion in cultured colonocytes. Gut 42: 208-213 |
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